Heart Regeneration Stem Cells And Beyond


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Heart Regeneration: Stem Cells And Beyond


Heart Regeneration: Stem Cells And Beyond

Author: Felix B Engel

language: en

Publisher: World Scientific

Release Date: 2012-03-22


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Injured mammalian hearts do not regenerate but scar. This is a major medical problem, as ischemic heart disease is among the leading causes of morbidity and mortality worldwide. Essential clues for human heart repair are uncovered when zebrafish and newt are found to regenerate cardiac muscle after injury.This book presents the major advances of the last decade in the field of cardiac regeneration. These recent advances include: demonstration that zebrafish, a genetically tractable system, can regenerate heart; the identification of several new stem cell populations in the heart; demonstration that stem cells can be used to improve heart function; and demonstration that induction of cardiomyocyte proliferation is a realistic future option to repair injured hearts. This book also provides detailed reviews of the research on model organisms capable of heart regeneration as well as innovative translational research to achieve regeneration in mammals, that comprises work on blood born stem cells, endogenous cardiac stem cells, paracrine factors, reawakening of cardiomyocyte proliferation, and bioengineering. More importantly, the book, in the concluding chapter, dovetails the studies with a comprehensive overview of clinical trials.

Heart Regeneration


Heart Regeneration

Author: Felix B. Engel

language: en

Publisher: World Scientific

Release Date: 2012


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This title presents the major advances of the last decade in the field of cardiac regeneration.

Regeneration: Stem Cells and Beyond


Regeneration: Stem Cells and Beyond

Author: Ellen Heber-Katz

language: en

Publisher: Springer Science & Business Media

Release Date: 2012-12-06


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In this issue of Current Topics in Microbiology and Immunology the authors present a unique range of examples of the regenerative response and the role of stem cells from the amphibian to human. It seems that all roads lead to cells that have the plasticity to become something else, not only in the amphibian but also in the mammal.