Graham L Patrick An Introduction To Medicinal Chemistry 5th Or 6th Editions Oxford
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An Introduction to Medicinal Chemistry
Author: Graham L. Patrick
language: en
Publisher: Oxford University Press, USA
Release Date: 2013-01-10
This volume provides an introduction to medicinal chemistry. It covers basic principles and background, and describes the general tactics and strategies involved in developing an effective drug.
An Introduction to Medicinal Chemistry
Author: Graham L. Patrick
language: en
Publisher: Oxford University Press
Release Date: 2023
The market-leader in medicinal chemistry: clear, supportive, and practical. It helps students to effortlessly make the link from theory to real-life applications using practical and focused coverage alongside a package of supportive online resources.
Advances in Medicinal Chemistry
Volume 4 of Advances in Medicinal Chemistry is comprised of six chapters on a wide range of topics in medicinal chemistry, including molecular modeling, structure-based drug design, organic synthesis, peptide conformational analysis, biological assessment, structure-activity correlation, and lead optimization. Chapter 1 presents an account about amino acid-based peptide mimetics corresponding to b-turn, loop, helical motifs in proteins as a probe of ligand-receptor and ligand-enzyme molecular interactions. Chapter 2 addresses new facets of the medicinal chemistry of the important anticancer drug Taxol® (paclitaxel). Chapter 3 relates an account of the search for new drugs for the treatment of malaria based on the natural product artemisinin. Chapter 4 applies computational chemistry to the evaluation of compound libraries for biological testing. Chapter 5 describes the construction of a 3-dimensional molecular model of the human thrombin receptor, the first protease-activated G-protein coupled receptor (PAR-1), as a means to explore the intermolecular contacts involved in agonist peptide recognition. Finally, Chapter 6 describes the research conducted at Merck on inhibitors of farnesyl transferase as a potential treatment for human cancers.