Functional Biomaterials Design Synthesis And Applications
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Functional Biomaterials Design, Synthesis and Applications
Early diagnosis of cancer is still a major challenge in cancer therapy. In recent years, the development of multifunctional nanomaterials has provided a new diagnosis and treatment platform to combat cancer. Polymer-inorganic nanomaterials with novel structures such as bowl-shaped/Janus/core-shell have drawn much attention owing to their diversity in composition or asymmetry in structure. More importantly, imparting unique optical, electrical, and magnetic properties to these nanocomposites can further extend their function repertoire. However, to fulfill this vision, fundamental understandings regarding strategies of precise synthesis, mechanisms of structure formation, in vivo synergistic effects in bioapplications, and biosafety of these materials are needed. Besides, nanomaterials with novel structures are well positioned for imaging-guided cancer theranostic. On one hand, nanomaterials themselves are suitable for imaging because of their intrinsic properties such as fluorescent or magnetic properties. On the other hand, nanomaterials can serve as functional platforms that integrate various therapeutic modalities including photothermal therapy, chemodynamic/ion-interference therapy, photodynamic therapy, and cuproptosis to efficiently kill cancer cells. This Research Topic aims at collecting works about synthesis, and biomedical applications of polymer/mesoporous inorganic nanomaterials, especially in the aspect of novel synthetic approaches for fabricating nanomaterials with unique structures. Additionally, we hope that in-depth research articles on this topic can provide insights into the mechanism of nanomaterials acting in cancer diagnosis and therapy. These include the mechanisms of customized drug load/release and synergistic effects in theranostics of these materials. Meanwhile, elucidations of key proteins’ roles in cancer development are also anticipated. Lastly, we hope that this topic can brew new ideas for the adaption of nanomaterials as platforms that allow for multimodal therapeutic modalities. The current Research Topic centers on the design, precise synthesis, and biomedical applications of nanomaterials. It aims to cover novel and promising research trends in nanomaterials with different morphology for cancer theranostics. Manuscripts from the following aspects, but not limited to, are welcomed: • Tailoring of asymmetrically structured (bowl-shaped, Janus, Yin Yang-like) polymer-inorganic nanomaterials; • Inorganic functional nanocrystals and functionalized mesoporous nanomaterials; • Design and synthesis of functional biomaterials, including lipids, polymers, and 2D materials • Non-viral DNA/mRNA delivery or drug/molecular inhibitor delivery; • Synthesizing biomaterials with novel nanostructures such as bowl-shaped, core-shell, spherical, Janus, and quantum dots; • Conquering drug resistance issues, tumor metastasis, and recurrence, as well as designing combination nanomedicines; • Dissecting the role of menin in prostate cancer and breast cancer: crosstalk between menin and AR signaling; • Multi-stimulus-responsive drug release and biological molecules.
3D Bioprinting in Regenerative Engineering
Regenerative engineering is the convergence of developmental biology, stem cell science and engineering, materials science, and clinical translation to provide tissue patches or constructs for diseased or damaged organs. Various methods have been introduced to create tissue constructs with clinically relevant dimensions. Among such methods, 3D bioprinting provides the versatility, speed and control over location and dimensions of the deposited structures. Three-dimensional bioprinting has leveraged the momentum in printing and tissue engineering technologies and has emerged as a versatile method of fabricating tissue blocks and patches. The flexibility of the system lies in the fact that numerous biomaterials encapsulated with living cells can be printed. This book contains an extensive collection of papers by world-renowned experts in 3D bioprinting. In addition to providing entry-level knowledge about bioprinting, the authors delve into the latest advances in this technology. Furthermore, details are included about the different technologies used in bioprinting. In addition to the equipment for bioprinting, the book also describes the different biomaterials and cells used in these approaches. This text: Presents the principles and applications of bioprinting Discusses bioinks for 3D printing Explores applications of extrusion bioprinting, including past, present, and future challenges Includes discussion on 4D Bioprinting in terms of mechanisms and applications
Soft Matter for Biomedical Applications
Author: Helena S Azevedo
language: en
Publisher: Royal Society of Chemistry
Release Date: 2021-06-07
Dynamic soft materials that have the ability to expand and contract, change stiffness, self-heal or dissolve in response to environmental changes, are of great interest in applications ranging from biosensing and drug delivery to soft robotics and tissue engineering. This book covers the state-of-the-art and current trends in the very active and exciting field of bioinspired soft matter, its fundamentals and comprehension from the structural-property point of view, as well as materials and cutting-edge technologies that enable their design, fabrication, advanced characterization and underpin their biomedical applications. The book contents are supported by illustrated examples, schemes, and figures, offering a comprehensive and thorough overview of key aspects of soft matter. The book will provide a trusted resource for undergraduate and graduate students and will extensively benefit researchers and professionals working across the fields of chemistry, biochemistry, polymer chemistry, materials science and engineering, nanosciences, nanotechnologies, nanomedicine, biomedical engineering and medical sciences.