Function Of Mrna
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Control of Messenger RNA Stability
This is the first comprehensive review of mRNA stability and its implications for regulation of gene expression. Written by experts in the field, Control of Messenger RNA Stability serves both as a reference for specialists in regulation of mRNA stability and as a general introduction for a broader community of scientists. - Provides perspectives from both prokaryotic and eukaryotic systems - Offers a timely, comprehensive review of mRNA degradation, its regulation, and its significance in the control of gene expression - Discusses the mechanisms, RNA structural determinants, and cellular factors that control mRNA degradation - Evaluates experimental procedures for studying mRNA degradation
MicroRNA Interference Technologies
Author: Zhiguo Wang
language: en
Publisher: Springer Science & Business Media
Release Date: 2009-06-11
MicroRNAs (miRNAs), endogenous noncoding regulatory mRNAs of around 22-nucleotides long, have rapidly emerged as one of the key governors of the gene expression regulatory program in cells of varying species, with ever-increasing implications in the control of the fundamental biological processes and in the pathogenesis of adult humans. The exciting findings in this field have inspired us with a premise and a promise that miRNAs will ultimately be taken to the heart for therapy of human disease. While miRNAs have been considered potential therapeutic targets for disease treatment, it remains obscured what strategies we can use to achieve the goal. In the past years, we have witnessed a rapid evolving of many creative, innovative, inventive strategies and methodologies pertinent to miRNA research and applications. These technologies have convincingly demonstrated their efficacy and reliability in producing gain-of-function or loss-of-function of miRNAs through targeting miRNA expression/biogenesis/function, providing new tools for elucidating miRNA functions and opening up a new avenue for the development of new agents targeting miRNAs for therapeutic aims. The present book provides comprehensive descriptions of these technologies and their applications to miRNA research and to new drug design for miRNA-related diseases. It starts with an overview of up-to-date knowledge of miRNA biology and the potential of miRNAs as therapeutic targets for human disease, followed by an introduction of the new concept of miRNA interference (miRNAi) and the perspectives of miRNAi technologies in general terms. In the following, each chapter introduces one of the miRNAi technologies with detailed descriptions of state-of-the-art design, procedures, principles and applications to basic research, R and D and clinical therapy.
Control of Gene Expression
Author: Alexander Kohn
language: en
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
The OHOLO Conferences have been convened annually from the Spring of 1956; the wide areas they have covered, from different and overlapping disciplines, can be seen from the following list: 1956 Bacterial Genetics (not published) 1957 Tissue Cultures in Virological Research (not published) 1958 Inborn and Acquired Resistance to Infection in Animals (not published) 1959 Experimental Approach to Mental Diseases (not published) 1960 Cryptobiotic Stages in Biological Systems* 1961 Virus-Cell Relationships** 1962 Biological Synthesis and Function of Nucleic Acids** 1963 Cellular Control Mechanism of Macromolecular Synthesis** 1964 Molecular Aspects of Immunology** 1965 Cell Surfaces** 1966 Chemistry and Biology of Psychotropic Agents (not published) 1967 Structure and Mode of Action of Enzymes** 1968 Growth and Differentiation of Cells In Vitro** 1969 Behaviour of Animal Cells in Culture** 1970 Microbial Toxins** 1971 Interaction of Chemical Agents with Cholinergic Mechanisms** 1972 Immunity in Viral and Rickettsial Diseases*** The participants who attend these Conferences are drawn from dif ferent scientific institutions in Israel and from many foreign countries; they are engaged in fields of study which represent widely divergent approaches to biology. Thus a distinguishing feature of the OHOLO meetings has been their multi-disciplinary nature. Published by Elsevier Publishing Co. , Amsterdam (1960). * ** Published by the Israel Institute for Biological Research, Ness Ziona. *** Published by Plenum Press, New York (1972). ix PREFACE x These small international conferences are also characterized by their relaxed atmosphere, with ample time for informal as well as formal discussions.