Engineering Analysis Of A Genetic Switch Modeling And Simulation Tools
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Engineering Analysis of a Genetic Switch: Modeling and Simulation Tools
The overall objective of this project was quantitatively explain the extraordinary stability of the lambda-phase lysogen given that the data on the lysis/lysogency switch dynamics didn't seem to be sufficient for explanation. Further, we aimed to explain the differential stability of a number of operator mutants constructed by John Little. Further, in all cases, we wished to explain the threshold response of the induction switch to different exposures to UV light. Then, based on this understanding we aimed to re-engineer this switch with different thresholds, cooperativities and stabilities.
Morphogenetic Engineering
Generally, spontaneous pattern formation phenomena are random and repetitive, whereas elaborate devices are the deterministic product of human design. Yet, biological organisms and collective insect constructions are exceptional examples of complex systems that are both self-organized and architectural. This book is the first initiative of its kind toward establishing a new field of research, Morphogenetic Engineering, to explore the modeling and implementation of “self-architecturing” systems. Particular emphasis is placed on the programmability and computational abilities of self-organization, properties that are often underappreciated in complex systems science—while, conversely, the benefits of self-organization are often underappreciated in engineering methodologies. Altogether, the aim of this work is to provide a framework for and examples of a larger class of “self-architecturing” systems, while addressing fundamental questions such as br” How do biological organisms carry out morphogenetic tasks so reliably? br” Can we extrapolate their self-formation capabilities to engineered systems?br” Can physical systems be endowed with information (or informational systems be embedded in physics) so as to create autonomous morphologies and functions?br” What are the core principles and best practices for the design and engineering of such morphogenetic systems?
Modelling, Analysis, and Simulation of Computer and Telecommunication Systems
Author: Maria Carla Calzarossa
language: en
Publisher: Springer Nature
Release Date: 2021-01-28
This book constitutes the post proceedings of the 28th International Symposium on Modelling, Analysis, and Simulation of Computer and Telecommunication Systems, MASCOTS 2020, held online -due to COVID -19- in Nice, France, in November 2020. The 17 full papers presented were carefully reviewed and selected from 124 submissions. The symposium collected the most relevant papers describing state-of-the-art research in the areas of the performance evaluation of computer systems and networks as well as in related areas.