Double Edged Swords Important Factors Connecting Metabolic Disorders And Cancer Development From Basic Research To Translational Applications Volume Ii

Double-Edged Swords: Important Factors Connecting Metabolic Disorders and Cancer Development - From Basic Research to Translational Applications, volume II

The relationship between metabolic dysfunctions and cancer development has been continuously evolving, informed by research efforts in the fields of epidemiology, endocrinology, cancer biology, chemistry, genomics, metabolomics among others. Metabolism and cancer can intersect at the physiological level, where metabolic disorders and cancer malignancies occur as comorbid or mutually-promoting conditions; or at the molecular level, where metabolic alterations regulate tumorigenesis and oncogenic/tumor-suppressive pathways govern the onset of metabolic syndromes. The increasingly complex spider web connecting metabolic dysfunctions and cancer development reveals both distinctive and shared mechanisms underlying different disease indications. It also points to unique opportunities, either through repurposing existing tools or discovering new strategies, to develop targeted therapies against a wide variety of metabolic and cancerous diseases. In our previous Research Topic: Double-edged Swords: Genetic Factors That Influence The Pathogenesis of Both Metabolic Disease and Cancer , we highlighted ten genetic factors/mechanisms that influence the pathogenesis of both metabolic disease and cancer. The attention it generated to date ( >110,000 article views, >22,000 article downloads, >500 citations) signals a fast-growing interest from scientific communities of different disciplines. We aim to highlight more recent advances to inform a diverse audience working on basic and translational research.

Double-edged swords: Important factors connecting metabolic disorders and cancer development - from basic research to translational applications

Double-edged Swords: Genetic Factors That Influence the Pathogenesis of Both Metabolic Disease and Cancer

Metabolic diseases and cancers account for half of all mortalities in the world, underscoring the significance of understanding the etiology of these diseases and developing effective therapies. Genomic research in the 21st century has brought cancer and metabolic disease, two once seemingly parallel ailments, as close to each other as they’ve ever been. Many genetic factors have been found to display functions regulating both cancer and metabolic disease. In this research topic: "Double-edged Swords: Genetic Factors That Influence The Pathogenesis of Both MetabolicDisease and Cancer", you will be introduced to individual genes, as well as genetic pathways that play important roles in influencing the progression of both metabolic disease and cancer. By no means covering an exhaustive list of genes qualified, this collection of articles rather serves as a precursor of what is yet to come in biomedical research. It paints the big picture of one of the major fields contributing to the future of “precision medicine”.