Development And Engineering Of Dopamine Neurons
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Development and Engineering of Dopamine Neurons
Author: Jeroen Pasterkamp
language: en
Publisher: Springer Science & Business Media
Release Date: 2009-12-16
Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
The Handbook of Dopamine
The Handbook of Dopamine captures current understanding of dopamine biology in the brain, including anatomical organization of dopamine neurons, their molecular and genetic diversity, synaptic and circuit connectivity, receptor function and signalling, through to diverse roles in behaviors and finally, dysfunction in disease. This volume compiles a comprehensive set of perspectives from a large number of leading scientists working in dopamine research. The volume describes the current state-of-the-field, summarizing knowledge that has been transformed in the last decade through the advent and application of sophisticated new technologies. - Offers up-to-date review of dopamine biology across fields - Explores the function and regulation of dopamine neurons in healthy behavior and also dysfunction in disease - Includes historical and future perspectives in the field of dopamine research
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Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely