Dbd Id Ac In
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Genetics and Epigenetics of Psychiatric Diseases, 2nd Edition
Psychiatric diseases have a highly complex etiology, aggregating in families but not segregating in a traditional Mendelian manner. Recent approaches to understanding the causes of psychiatric disease have focused on describing the genetic contribution to major psychiatric illnesses; the use of large-scale genome-wide association studies (GWAS) and exome sequencing has enabled a systematic exploration of genetic risk factors and identified over 100 independent genomic loci significantly associated with psychiatric diseases; however, there remains uncertainty about the causal genes involved in disease pathogenesis, and how their function is regulated. Since many GWAS variants reside in non-coding regions, the disease-associated common variants might be enriched in regulatory domains, including enhancers and regions of active chromatin state. These lead us to focus on the possible role of non-sequence-based genomic variation in health and disease. Of particular interest are epigenetic modifications that regulate gene expression through modifications to DNA, RNA, histone proteins, and chromatin. The availability of high-throughput profiling methods for quantifiying epigenomic modifications in large numbers of samples has enabled us to perform epigenome-wide association studies (EWAS) aimed at screening methylomic variations associated with environmental exposure and disease. Thus systematic integration of genetic, epigenetic and epidemiological approaches will contribute to improving our understanding of the molecular mechanisms underlying disease phenotypes.
Process Analyzer Sample-Conditioning System Technology
Author: Robert E. Sherman
language: en
Publisher: John Wiley & Sons
Release Date: 2002-01-11
"Sampling systems are one part chemistry, one part engineering (electrical, chemical, mechanical, civil, and maybe even software). No one person possesses all of the knowledge required. Bob (Sherman) comes as close as anyone." -John A. Crandall, V.P. Sales Americas, ABB Process Analytics This resource provides both novice and experienced technologist with the technical background necessary to choose sample conditioning system components that will allow the process analyzer system to function reliably with minimal maintenance. The conditioned process sample presented to the process analyzer should be of similar quality to the calibration material used to zero and span the analyzer. Filling a long-standing void in the process field, this book addresses the system concept of Process Analyzer Sample-Conditioning Technology in light of the critical importance of delivering a representative sample of the process stream to the process analyzer. Offering detailed descriptions of the equipment necessary to prepare process samples, and listings of two or more vendors (when available) for equipment reviewed, Process Analyzer Sample-Conditioning System Technology discusses: * The importance of a "truly representative sample" * Sample probes, transfer lines, coolers, and pumps * Sample transfer flow calculations for sizing of lines and system components * Particulate filters, gas-liquid and liquid-liquid separation devices * Sample pressure measurement and control * Enclosures and walk-in shelters, their electrical hazard ratings and climate control systems With extensive system and component examples-including what worked and what didn't-Process Analyzer Sample-Conditioning System Technology gives the new technologist a basic source of design parameters and performance-proven components as well as providing the experienced professional with a valuable reference resource to complement his or her experience.
Amphioxus Immunity
Amphioxus Immunity: Tracing the Origin of Human Immunity covers a remarkable range of information about Amphioxus and its evolutionary context. This compilation of what is currently known about Amphioxus, with a sharp focus on its immune system, includes 13 topics, such as: - Amphioxus as a model for understanding the evolution of vertebrates - basic knowledge of immunology - immune organs and cells of amphioxus - a genomic and transcriptomic view of the Amphioxus immunity - pattern recognition system in Amphioxus - transcription factors in Amphioxus - the complement system of Amphioxus - the oxidative burst system in Amphioxus - immune effectors in Amphioxus - lipid signaling of immune response in Amphioxus - apoptosis in amphioxus; primitive adaptive immune system of Amphioxus - and future research directions This valuable reference book is loaded with information that will be useful for anyone who wishes to learn more about the origin of vertebrates and adaptive immunity. - Provides new evidence on the origin of the adaptive immune system, the evolution of innate immunity, and evolution-stage specific immune defense mechanisms - Not only presents the cells and molecules involved in the adaptive immune response in Amphioxus, but also characterizes the origination and evolution of the gene families and pathways involved in innate immunity - Includes much pioneering work, from the molecular, genomic, and cellular to the individual level