Database Journal
Download Database Journal PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Database Journal book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages.
Open Access Databases and Datasets for Drug Discovery
Open Access Databases and Datasets for Drug Discovery Timely resource discussing the future of data-driven drug discovery and the growing number of open-source databases With an overview of 90 freely accessible databases and datasets on all aspects of drug design, development, and discovery, Open Access Databases and Datasets for Drug Discovery is a comprehensive guide to the vast amount of “free data” available to today’s pharmaceutical researchers. The applicability of open-source data for drug discovery and development is analyzed, and their usefulness in comparison with commercially available tools is evaluated. The most relevant databases for small molecules, drugs and druglike substances, ligand design, protein 3D structures (both experimental and calculated), and human drug targets are described in depth, including practical examples of how to access and work with the data. The first part is focused on databases for small molecules, followed by databases for macromolecular targets and diseases. The final part shows how to integrate various open-source tools into the academic and industrial drug discovery and development process. Contributed to and edited by experts with long-time experience in the field, Open Access Databases and Datasets for Drug Discovery includes information on: An extensive listing of open access databases and datasets for computer-aided drug design PubChem as a chemical database for drug discovery, DrugBank Online, and bioisosteric replacement for drug discovery supported by the SwissBioisostere database The Protein Data Bank (PDB) and macromolecular structure data supporting computer-aided drug design, and the SWISS-MODEL repository of 3D protein structures and models PDB-REDO in computational aided drug design (CADD), and using Pharos/TCRD for discovering druggable targets Unmatched in scope and thoroughly reviewing small and large open data sources relevant for rational drug design, Open Access Databases and Datasets for Drug Discovery is an essential reference for medicinal and pharmaceutical chemists, and any scientists involved in the drug discovery and drug development.
Databases for Data-Centric Geotechnics
Databases for Data-Centric Geotechnics forms a definitive reference and guide to databases in geotechnical and rock engineering, to enhance decision-making in geotechnical practice using data-driven methods. This first volume pertains to site characterization. The opening chapter presents an in-depth analysis of site data attributes, including the establishment of a new taxonomy of site data under “4S” (site generalizations, spatial features, sampling characteristics, and smart data) to provide a novel agenda for data-driven site characterization. Type 3 machine learning methods (disruptive value) are possible as sensors become more pervasive and more intelligent. A comprehensive overview of site characterization information is also presented with a focus on its availability, coverage, value to decision making, and challenges. The remaining 13 chapters cover databases of soil and rock properties and the application of these databases to rock socket behavior, rock classification, settlement on soft marine clays, permeability of fine-grained soils, and liquefaction among others. The databases were compiled from studies undertaken in many countries including Austria, Australia, Brazil, Canada, China, France, Finland, Germany, India, Iran, Japan, Korea, Malaysia, Mexico, New Zealand, Norway, Singapore, Sweden, Thailand, the United Kingdom, and the United States. This volume on site characterization is a companion to the volume on geotechnical structures. Databases for Data-Centric Geotechnics represents the most diverse and comprehensive assembly of database research in a single publication (consisting of two volumes) to date. It follows from Model Uncertainties for Foundation Design, also published by CRC Press, and suits specialist geotechnical engineers, researchers and graduate students.
Databases for Data-Centric Geotechnics
Databases for Data-Centric Geotechnics forms a definitive reference and guide to databases in geotechnical and rock engineering, to enhance decision-making in geotechnical practice using data-driven methods. This second volume pertains to geotechnical structures. The opening chapter presents a substantial survey of performance databases and the effectiveness of our prediction models in matching the field measurements in these databases, based on (1) full-scale field tests, (2) 39 prediction exercises organized as a part of international conferences, and (3) comparison between numerical analyses and in-situ or field measurements conducted by the French LCPC. The focus is on the evaluation of the statistical degree of confidence in predicting various of quantities of interest such as capacity and deformation. The following 18 chapters then present databases on the performance of shallow foundations, spudcan foundations, deep foundations, anchors and pipelines, retaining systems and excavations, and landslides. The databases were compiled from studies undertaken in many countries such as Australia, Belgium, Bolivia, Brazil, Canada, China, Egypt, France, Germany, Hungary, Iran, Ireland, Japan, Kenya, Malaysia, Netherlands, Norway, Poland, Portugal, South Africa, the United Kingdom and the United States. This volume on geotechnical structures is a companion to the volume on site characterization. Databases for Data-Centric Geotechnics represents the most diverse and comprehensive assembly of database research in a single publication (consisting of two volumes) to date. It follows from Model Uncertainties for Foundation Design, also published by CRC Press, and suits specialist geotechnical engineers, researchers and graduate students. Chapter 10 of this book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons [Attribution (CC BY)] 4.0 license.