Chapitre 6 G Quadruplex Structure Detection Et Fonctions
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Chapitre 6 - G-quadruplex : structure, détection et fonctions
Les G-quadruplex (G4), structures secondaires pouvant être adoptées par les acides nucléiques, jouent des rôles biologiques dans de nombreux processus cellulaires : maintenance des télomères, réplication cellulaire, réarrangements génomiques, réponse aux dommages de l’ADN, régulation transcriptionnelle. Par ailleurs, dans le génome humain, il existe une forte présence de séquences potentiellement capables de former des G4. Ces observations mènent à la question de comment ces séquences se forment in vivo, sont maintenues dans les génomes et comment elles évoluent. Mots-clés : structure 3D, G-Quadruplex, NGS, instabilité génétique, génomique, bioinformatique. DOI : 10.51926/ISTE.9119.ch6
Function and Evolution of Repeated DNA Sequences
Author: Guy-Franck Richard
language: en
Publisher: John Wiley & Sons
Release Date: 2024-01-31
The genome of a living being is composed of DNA sequences with diverse origins. Beyond single-copy genes, whose product has a biological function that can be inferred by experimentation, certain DNA sequences, present in a large number of copies, escape the most refined approaches aimed at elucidating their precise role. The existence of what 20th century geneticists had already perceived (and wrongly described as "junk DNA"!) was confirmed by the sequencing of the first complex genomes, including that of Homo sapiens. A large part of what defines a living thing is not unique, but repeated, sometimes a very large number of times, increasing in complexity with successive duplications and multiplication. Understanding and defining the many functions of this myriad of repeated sequences, as well as their evolution through natural selection, has become one of the major challenges for 21st century genomics.
Enzymes in RNA Science and Biotechnology
Enzymes in RNA Science and Biotechnology, Volume 691 in the Methods in Enzymology series, highlights new advances in the field, including chapters on Reverse transcriptase Part I (discovery, preparation, general utilization, MarathonRT for routine RT-PCR and for cDNA synthesis on challenging RNA templates Structured RNAs, repeat RNAs and more, Engineering TNA Polymerases Through Iterative Cycles of Directed Evolution, Reverse transcriptase Part II (RNA structure mapping and determination), RNA G-quadruplex (rG4) structure detection using RTS and SHALiPE assays, tRNA Structure-seq in vivo and in droplets, Capture the in vivo intact RNA structurome by CAP-STRUCTURE-seq, and more. - Provides the authority and expertise of leading contributors from an international board of authors - Presents the latest release in Methods in Enzymology serials - Updated release includes the latest information on Enzymes in RNA science and biotechnology