Cellular And Molecular Bases Of Biological Clocks
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Cellular and Molecular Bases of Biological Clocks
Author: Leland N. Jr. Edmunds
language: en
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
An intriguing class of biological periodicity consists of rhythms with about 24-hour periods occurring at every level of eukaryotic organization. Progress is being made in understanding these rhythms. The six chapters of this work include a brief introduction to circadian (24-hour) rhythms, a survey of circadian organization at the cellular level, and a description of the important microorganisms that have served as experimental models for biochemical analysis. Also considered are relations between cell division cycles and circadian oscillators, as well as some general and theoretical aspects. Where appropriate, parallels are drawn to neuronal oscillators. This volume will introduce and critically appraise modern chronobiology; its extensive illustrations and comprehensive up-to-date bibliography will make it an authoritative reference.
Biochemical Oscillations and Cellular Rhythms
Author: A. Goldbeter
language: en
Publisher: Cambridge University Press
Release Date: 1996-01-26
This book addresses the molecular bases of some of the most important biochemical rhythms known at the cellular level. Clarifying the mechanism of these oscillatory phenomena is of key importance for understanding the origin as well as the physiological function of these rhythms, and the conditions in which simple periodic behaviour transforms into complex oscillations, including bursting and chaos. The approach rests on the analysis of theoretical models closely related to experimental observations. Among the main rhythms considered are glycolytic oscillations observed in yeast and muscle, oscillations of cyclic AMP in Dictyostelium amoebae, intracellular calcium oscillations observed in a variety of cell types, the mitotic oscillator that drives the cell division cycle in eukaryotes, and circadian oscillations of the period protein (PER) in Drosophila. For each of these phenomena, experimental facts are reviewed and mathematical models presented.
Molecular Biology of Circadian Rhythms
This text begins with a general introduction to biochemical and biophysical aspects of circadian timing, then proceeds to its essential focus on collating the newest information on molecular mechanisms of circadian rhythms. It includes a chapter on the implications for clinical research on affective disorders, sleep disorders, and the relevance for therapeutic treatment, as well as coverage of multiple oscillators and hormonal rhythms. Sections include: Molecular Control of Circadian Rhythms: Animal Models Molecular Control of Circadian Rhythms: From Cyanobacteria to Plants Circadian Organization in Complex Organisms. Chapter topics include examinations of circadian rhythms in non-mammalian vertebrates, neurospora, and humans.