Bioinformatics Of Non Coding Rnas With Applications To Biomedicine Recent Advances And Open Challenges
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Bioinformatics of Non-Coding RNAs with Applications to Biomedicine: Recent Advances and Open Challenges
Author: Carlo Maria Croce
language: en
Publisher: Frontiers Media SA
Release Date: 2017-01-27
The recent discovery of small and long non-coding RNAs (ncRNAs) has represented a major breakthrough in the life sciences. These molecules add a new layer of complexity to biological processes and pathways by revealing a sophisticated and dynamic interconnected system whose structure is just beginning to be uncovered. Genetic and epigenetic aberrations affecting ncRNA gene sequences and their expression have been linked to a variety of pathological conditions, including cancer, cardiovascular and neurological diseases. Latest advances in the development of high throughput analysis techniques may help to shed light on the complex regulatory mechanisms in which ncRNA molecules are involved. Bioinformatics tools constitute a unique and essential resource for non-coding RNA studies, providing a powerful technology to organize, integrate and analyze the huge amount of data produced daily by wet biology experiments in order to discover patterns, identify relationships among heterogeneous biological elements and formulate functional hypotheses. This Research Topic reviews current knowledge, introduces novel methods, and discusses open challenges of this exciting and innovative field in connection with the most important biomedical applications. It consists of four reviews and six original research and methods articles, spanning the full scope of the Research Topic.
A Comprehensive Guide Through the Italian Database Research Over the Last 25 Years
This book offers readers a comprehensive guide to the evolution of the database field from its earliest stages up to the present—and from classical relational database management systems to the current Big Data metaphor. In particular, it gathers the most significant research from the Italian database community that had relevant intersections with international projects. Big Data technology is currently dominating both the market and research. The book provides readers with a broad overview of key research efforts in modelling, querying and analysing data, which, over the last few decades, have became massive and heterogeneous areas.
RNA Technologies and Their Applications
Author: Volker A. Erdmann
language: en
Publisher: Springer Science & Business Media
Release Date: 2010-09-02
RNA technologies are the driving forces of modern medicine and biotechnology. They combine the fields of biochemistry, chemistry, molecular biology, cell biology, physics, nanotechnology and bioinformatics. The combination of these topics is set to revolutionize the medicine of tomorrow. After more than 15 years of extensive research in the field of RNA technologies, the first therapeutics are ready to reach the first patients. Thus we are witnessing the birth of a very exciting time in the development of molecular medicine, which will be based on the methods of RNA technologies. This volume is the first of a series. It covers various aspects of RNA interference and microRNAs, although antisense RNA applications, hammerhead ribozyme structure and function as well as non-coding RNAs are also discussed. The authors are internationally highly respected experts in the field of RNA technologies.