An Investigation Of Microrna Target Regulation Mechanisms Using An Integrative Approach
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An investigation of microRNA target regulation mechanisms using an integrative approach
Author: Ulf Schmitz
language: en
Publisher: Logos Verlag Berlin GmbH
Release Date: 2015-06-29
This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.
Biocomputing 2020 - Proceedings Of The Pacific Symposium
The Pacific Symposium on Biocomputing (PSB) 2020 is an international, multidisciplinary conference for the presentation and discussion of current research in the theory and application of computational methods in problems of biological significance. Presentations are rigorously peer reviewed and are published in an archival proceedings volume. PSB 2020 will be held on January 3 -7, 2020 in Kohala Coast, Hawaii. Tutorials and workshops will be offered prior to the start of the conference.PSB 2020 will bring together top researchers from the US, the Asian Pacific nations, and around the world to exchange research results and address open issues in all aspects of computational biology. It is a forum for the presentation of work in databases, algorithms, interfaces, visualization, modeling, and other computational methods, as applied to biological problems, with emphasis on applications in data-rich areas of molecular biology.The PSB has been designed to be responsive to the need for critical mass in sub-disciplines within biocomputing. For that reason, it is the only meeting whose sessions are defined dynamically each year in response to specific proposals. PSB sessions are organized by leaders of research in biocomputing's 'hot topics.' In this way, the meeting provides an early forum for serious examination of emerging methods and approaches in this rapidly changing field.
Integrated Uncertainty in Knowledge Modelling and Decision Making
This book constitutes the refereed proceedings of the International Symposium on Integrated Uncertainty in Knowledge Modeling and Decision Making, IUKM 2013, held in Beijing China, in July 2013. The 19 revised full papers were carefully reviewed and selected from 49 submissions and are presented together with keynote and invited talks. The papers provide a wealth of new ideas and report both theoretical and applied research on integrated uncertainty modeling and management.