Alzheimer S Disease New Insights Into Biomechanisms And Therapeutic Target

Alzheimer's disease: new insights into biomechanisms and therapeutic target

With the prevalence of Alzheimer's disease on the rise among aging populations, it becomes crucial to acquire a comprehensive understanding of the underlying biomechanisms to enhance preventive measures for patients. Recent advances in the elucidation of basic biomechanisms such as the major role of the influential genetic factor TREM2 in the immunological basis of Alzheimer’s disease and the establishment of mechanobiology with relevance to Alzheimer’s diseases, hold promising translational value and potential for clinical applications. This research topic aims to elucidate the most recent progress in the field of basic and clinical research. Specifically, we will focus on areas such as the pathogenesis of Alzheimer's disease, neurodegenerative processes and early changes, perception and cognition deficits, immune regulation, as well as new therapeutic targets and innovative strategies. The topic editorial team is dedicated to advancing the field of Alzheimer's disease and creating a platform which future progress can be built upon.

New Insights into Intracellular Pathways and Therapeutic Targets in CNS Diseases

The intracellular signalling network machinery, responding to different micro-environmental cues, regulates all aspects of cellular physiology, including metabolism, gene expression and modification, proliferation, differentiation and programmed cell death. Indeed, changes in the expression of cell surface receptors and/or their mutations, as well as ligand abundance, can have profound effects on cell physiology of the central nervous system and disarray of cell signalling often lies beneath the cause of neuronal diseases. New interesting knowledge has been recently gathered demonstrating the importance of canonical developmental pathways such as Sonic Hedgehog (SHH), Wnt/b-catenin and Notch-3 in neuronal homeostasis. As well, the role of autophagosomes generating pathways has recently been involved in conditions such as neuroinflammation, Alzheimer's and Parkinson’s diseases, brain tumours, and damages due to cerebral ischemia and reperfusion, with a specific attention on the accumulation of ROS-generating damaged mitochondria.

New Insights Into Adult Neurogenesis and Neurodegeneration: Challenges for Brain Repair