Alk It Off
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Walking
Walking is something most of us do every day – but we should be doing more of it. 63% of Canadians aren't getting the recommended amount of daily exercise, and it's adding up: heart disease, obesity, and high blood pressure are all on the rise. But something as simple as taking a few extra steps a day can make a huge difference: moving more leads to more energy, improved sleep quality, and better heart health. And John Stanton knows how to get people moving. As the founder and president of Walking/Running Room, North America's largest chain of special stores for walkers and runners, he has inspired people across the nation to develop healthier lifestyles one step at a time. Walking: A Complete Guide to Walking for Fitness, Health, and Weight Loss is the perfect companion for your own journey to good health. With three program categories to fit every type of activity level, from non-walkers to avid walkers, there is a program in here for you. In this comprehensive guide, you'll learn how to: * Set realistic goals * Design your own training program * Find the level of walking that's right for you * Choose the best shoes and walking wear for your needs * Prevent and treat common injuries * Enhance your walking with optimum nutrition Let John Stanton show you the way to a healthier, happier lifestyle... one step at a time.
Therapeutic Strategies to Overcome ALK Resistance in Cancer
Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment. - Explains the biology of ALK RTK, focusing on its tissue expression, structure and functionality - Presents an overview of current treatments and the benefits of ALK TKI in lung and other cancer types, such as ALCL, neuroblastoma and inflammatory myofibroblastic tumor - Encompasses information on systemic treatments other than TKI, including chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC
Tectonic Archaeology
Author: Gina L. Barnes
language: en
Publisher: Archaeopress Publishing Ltd
Release Date: 2022-12-29
The effects of tectonic processes on archaeological sites are evidenced by earthquake damage, volcanic eruptions, and tsunami destruction, but these processes also affect a broader sphere of landform structures, environment, and climate. An overview of tectonic archaeology is followed by a detailed summary of geoarchaeological fieldwork in Japan.