A Manual For Biomaterials Scaffold Fabrication Technology
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A Manual For Biomaterials/scaffold Fabrication Technology
Author: Gilson Khang
language: en
Publisher: World Scientific Publishing Company
Release Date: 2007-07-03
Tissue engineering has been recognized as offering an alternative technique to whole-organ and tissue transplantation for diseased, failed, or malfunctioned organs. To reconstruct a new tissue via tissue engineering, the following triad components are needed: (1) cells which are harvested and dissociated from the donor tissue; (2) biomaterials as scaffold substrates in which cells are attached and cultured, resulting in implantation at the desired site of the functioning tissue; and (3) growth factors which promote and/or prevent cell adhesion, proliferation, migration, and differentiation. Of these three key components, scaffolds play a critical role in tissue engineering. This timely book focuses on the preparation and characterization of scaffold biomaterials for the application of tissue-engineered scaffolds. More importantly, it serves as an experimental guidebook on the standardization of the fabrication process and characterization of scaffolding technology.
Handbook of Intelligent Scaffolds for Tissue Engineering and Regenerative Medicine
Millions of patients suffer from end-stage organ failure or tissue loss annually, and the only solution might be organ and/or tissue transplantation. To avoid poor biocompatibility–related problems and donor organ shortage, however, around 20 years ago a new, hybridized method combining cells and biomaterials was introduced as an alternative to whole-organ and tissue transplantation for diseased, failing, or malfunctioning organs—regenerative medicine and tissue engineering. This handbook focuses on all aspects of intelligent scaffolds, from basic science to industry to clinical applications. Its 10 parts, illustrated throughout with excellent figures, cover stem cell engineering research, drug delivery systems, nanomaterials and nanodevices, and novel and natural biomaterials. The book can be used by advanced undergraduate- and graduate-level students of stem cell and tissue engineering and researchers in macromolecular science, ceramics, metals for biomaterials, nanotechnology, chemistry, biology, and medicine, especially those interested in tissue engineering, stem cell engineering, and regenerative medicine.
Introduction to Biomaterials
Author: Donglu Shi
language: en
Publisher: World Scientific Publishing Company Incorporated
Release Date: 2006
1. Introduction to bioceramics. 1.1. Bioactive materials. 1.2. References -- 2. Bioactive ceramics : structure, synthesis, and mechanical properties. 2.1. Structure of hydroxyapatite. 2.2. Synthesis of hydroxyapatite powder. 2.3. Mechanical properties of hydroxyapatite. 2.4. Other bioceramics. 2.5. References. 2.6. Problems -- 3. Bioceramic processing. 3.1. Fabrication and mechanical properties of porous bioceramics. 3.2. Coating of bioceramic thick films on bio-inert porous subs. 3.3. Coating on dense substrates. 3.4. Hydroxyapatite coatings for non-hard tissue applications. 3.5. Composites. 3.6. Summary. 3.7. References. 3.8. Problems -- 4. Coating of hydroxyapatite onto inner pore surfaces of the reticulated alumina. 4.1. Hydroxyapatite coating methods and characterization. 4.2. Adhesion of hydroxyapatite film on alumina substrate. 4.3. References. 4.4. Problems -- 5. Properties and characterization of biomaterials. 5.1. Characterization of ceramics. 5.2. Bioactive properties and hard tissue prosthetics. 5.3. Measurements of growth and dissolution of hydroxyapatite ceramics. 5.4. In vitro test conducted in this reasearch. 5.5. Mechanical properties. 5.6. References. 5.7. Problems -- 6. Bioactivity of hydroxyapatite. 6.1. General aspects. 6.2. In vitro testing materials and preparation. 6.3. Characterization of immersion solution. 6.4. Morphology of the reacted surfaces. 6.5. References. 6.6. Problems -- 7. Hydroxyapatite deposition mechanisms. 7.1. Material synthesis and hydroxyapatite coating. 7.2. Mechanisms of bioactivity. 7.3. References. 7.4. Problems -- 8. Biomedical metallic materials. 8.1. Microstructures and processing. 8.2. Corrosion resistance of metals. 8.3. Biological tolerance of metal. 8.4. Stainless steel. 8.5. Cobalt-based alloys. 8.6. Titanium and its alloys. 8.7. TiNi shape memory alloy. 8.8. Summary. 8.9. References. 8.10. Problems -- 9. Polymer basics. 9.1. Classification of polymers. 9.2. Characteristics of polymer. 9.3. Synthesis of polymers. 9.4. References. 9.5. Problems -- 10. Naturally occurring polymer biomaterials. 10.1. General introduction to proteins. 10.2. Collagen. 10.3. Alginate. 10.4. Chitin and chitosan. 10.5. References. 10.6. Problems -- 11. Synthetic non-biodegradable polymers. 11.1. Polyethylene. 11.2. Poly (methyl methacrylate). 11.3. Polyester. 11.4. Polycarbonate. 11.5. Polyamides. 11.6. Polyurethane. 11.7. Pofysulfones. 11.8. Poly (ether ether ketone). 11.9. References. 11.10. Problems -- 12. Synthetic biodegradable polymers. 12.1. Aliphatic polyester. 12.2. Poly (propylene fumarate). 12.3. Polyamino acid. 12.4. References. 12.5. Problems -- 13. Polymer matrix composite biomaterials. 13.1. Fiber reinforced composites. 13.2. Filler reinforced composites. 13.3. Methods to improve the interfacial bonding between phases in composites. 13.4. References. 13.5. Problems -- 14. Biomaterials for tissue engineering. 14.1. General aspects of biomaterials used for tissue engineering. 14.2. Representative biomaterials used for tissue engineering. 14.3. Biomaterial constructs for tissue engineering : scaffolds. 14.4. References. 14.5. Problems -- 15. Cells and biomolecules for tissue engineering. 15.1. Cells for tissue engineering. 15.2. Growth factor delivery in tissue engineering. 15.3. Regulatory matrix proteins. 15.4. References. 15.5. Problems -- 16. Transport and vascularization in tissue engineering. 16.1. Transport in engineered tissue. 16.2. Vascularization. 16.3. References. 16.4. Problems -- 17. Host response to tissue engineered grafts. 17.1. The foreign body response to synthetic components. 17.2. Response to biological components. 17.3. References. 17.4. Problems -- 18. Other important issues and future challenges in tissue engineering. 18.1. Organ replacement and regeneration. 18.2. Organotypic and histiotypic models. 18.3. Mechanotransduction. 18.4. Future challenges. 18.5. References. 18.6. Problems