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The Stille Reaction

A guide to making optimal use of one of the most important tools available to today's synthetic organic chemist Compatible with virtually all functional groups without protection and capable of forming carbon-carbon bonds under neutral conditions-often with complete stereospecificity-the Stille reaction is an indispensable component of the synthetic organic chemist's toolkit. In the years since Stille's pioneering work, chemists have developed a vast number of applications for this incredibly versatile metal-catalyzed cross-coupling reaction. This paperback edition of the 50th volume in the definitive Organic Reactions series describes many of those uses. Drawing upon their considerable experience as professional synthetic organic chemists who have worked extensively with the Stille reaction, the authors approach their subject from the preparative viewpoint, paying particular attention throughout to limitations, interfering influences, effects of structure, and the selection of experimental techniques. Focusing primarily on the single reaction of the Stille reaction, they provide comprehensive coverage of: * Experimental conditions and selecting optimal experimental parameters * Traditional and recently developed experimental procedures * Side reactions and techniques for avoiding them * Documented reactions-33 tables list 570 reactions, complete withconditions, yields, structures of major products, and common failures * Easy-to-follow recipes for casual users of the Stille reaction The Stille Reaction is an indispensable working resource for all synthetic organic chemists, especially medicinal chemists. It is also an excellent graduate-level text for students of organic and medicinal chemistry.

Topology Optimization in Structural and Continuum Mechanics

The book covers new developments in structural topology optimization. Basic features and limitations of Michell’s truss theory, its extension to a broader class of support conditions, generalizations of truss topology optimization, and Michell continua are reviewed. For elastic bodies, the layout problems in linear elasticity are discussed and the method of relaxation by homogenization is outlined. The classical problem of free material design is shown to be reducible to a locking material problem, even in the multiload case. For structures subjected to dynamic loads, it is explained how they can be designed so that the structural eigenfrequencies of vibration are as far away as possible from a prescribed external excitation frequency (or a band of excitation frequencies) in order to avoid resonance phenomena with high vibration and noise levels. For diffusive and convective transport processes and multiphysics problems, applications of the density method are discussed. In order to take uncertainty in material parameters, geometry, and operating conditions into account, techniques of reliability-based design optimization are introduced and reviewed for their applicability to topology optimization.

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