Pathways Of Promise
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The Power and Promise of Pathways
High school students are more fully engaged in their education and postsecondary decision-making when they understand the "real life" connections between education and future careers. The Power and Promise of Pathways: How to Prepare All American Students for Career and Life Success, written by the National Center for College and Career Transitions (NC3T) founder Hans Meeder, offers educators a comprehensive look at secondary pathways from the early planning stage to full implementation along with key issues relating to the transformation a pathways initiative brings to an entire community. Topics are presented with current research and best practice examples: Defining career and life readiness and why this is important. Developing a comprehensive pathways system that addresses six key components. Building a career development system that deeply impacts how students and their parents plan for postsecondary education and careers. Integrating college, career, and life readiness into exciting and engaging pathway programs that also address critical workforce needs and opportunities. Collaborating meaningfully with employer and community organizations in order to form mutually beneficial partnerships that offer opportunities for students to experience the world beyond school. Integrating dynamic teaching and learning approaches into pathway programs so that students also learn important life and employability skills.Hans Meeder is president of the National Center for College and Career Transitions, an organization that provides coaching and technical assistance for schools and communities involved in launching a college and career pathways system. Hans, former Deputy Assistant Secretary at the U.S. Department of Education, is an internationally recognized speaker and author with expertise in pathways, school reform, career and technical education, and STEM education.
Druggable Lipid Signaling Pathways
Lipids are responsible not just for constituting cellular membrane but also for storing energy, transducing signaling, and modifying proteins. Bioactive lipids, or lipid mediators, transduce signaling as intracellular messenger like phosphoinoitides, and also regulate cell-cell communication through G protein-coupled receptors (GPCRs) that are potentially valuable drug targets in many diseases. Until now, about 40 GPCRs within ~300 rhodopsin-like (class A) GPCRs, are identified as lipid GPCRs. Advances of lipid research have enabled to develop novel small molecules targeting lipid GPCRs for several diseases. Most notably, fingolimod (FTY720), a sphingosine 1-phosphate (S1P) receptor modulator, became the first FDA-approved medicine as an orally bioavailable drug for treating relapsing forms of multiple sclerosis (MS). In addition to fingolimod, other drugs targeting lipid GPCRs had been developed such as latanoprost (prostaglandin F2a analogue, used for ocular hypertension and glaucoma), epoprostenol and treprostinil (prostaglandin I2 analogue, used for pulmonary arterial hypertension), montelukast and pranlukast (cysteinyl leukotriene receptor antagonist, used for asthma and allergies), etc. Novel drugs are also expected like lysophosphatidic acid (LPA) receptor antagonist for treatment of pulmonary fibrosis. Drug development targeting lipid signalling pathways are backdated to more than a century, when aspirin was synthesized and selling by Bayer, while the basic mechanism of aspirin's effects (block prostanoid synthesis by inhibiting cyclooxygenases) had not been discovered until 1970s. Nowadays, non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprophen are commonly used as antipyretic analgesics and available readily over-the-counter oral drugs. Both upstream and downstream enzymes, such as phospholipase A2s and prostaglandin E synthases, respectively, are also potential therapeutic targets for inflammatory diseases. Recent studies of lipid metabolism expand the lipid biology field from pro-inflammatory lipid mediators to anti-inflammatory epoxy fatty acids (epoxyeicosatrienoic acids), and also omega-3 fatty acid-derived pro-resolving lipid mediators (lipoxin, resolvin, and neuroprotectin). These bioactive lipids, their metabolic pathways and receptors are of great interest in developing next-generation anti-inflammatory and pro-resolving drugs for a wide variety of diseases including. This book summarizes not only historical overview of lipid signaling pathways but also provides summary of cutting-edge studies that may provide some hints of novel “druggable” lipid signaling targets.
Pathways to the King
Author: Rob Reimer
language: en
Publisher: Carpenter's Son Publishing
Release Date: 2024-03-11
The church in America desperately needs revival. The percentage of people who attend church in America today is lower than ever before. But how do we experience revival? How do we usher in God’s Kingdom on Earth and see the next great spiritual awakening? It starts with you. God wants you to draw near to Jesus and to be a carrier of His Kingdom. He wants you to experience the reality and fullness of His Kingdom, and He wants you to expand the Kingdom to others – just like Jesus did. Pathways to the King provides you with 8 Kingdom pathways that you’ll need to incorporate and internalize in order to experience and expand God’s Kingdom on Earth. These pathways are discussed in great detail, are securely rooted in biblical truths, and are illustrated by poignant examples from Scripture, from the lives of believers, and from great Christians throughout history. When you begin to walk down these pathways, you will develop intimacy, authority, and power in Christ and become a Kingdom-minded person living out the compelling life of the Spirit.