Observation Of The Associated Production Of A Single Top Quark And A W Boson In Pp Collisions At Sqrt S

Molecular Determinants of Head and Neck Cancer

Squamous cell cancers of the head and neck (SCCHN), also known as head and neck cancers (HNC) encompass malignancies of the oral cavity, larynx, nasopharynx and pharynx, and are diagnosed in over 500,000 patients worldwide each year, accounting for 5% of all malignancies. It is estimated that approximately 50,000 patients develop head and neck cancer annually in the United States, of whom approximately 50% succumb to this cancer. For most cases of SCCHN, treatment is multimodal, often combining surgery or irradiation with chemotherapy; even successfully treated patients frequently experience durable and severe side effects. Improving cure rates and reducing chronic morbidity are urgent clinical needs for head and neck cancer. However, in contrast to cancer types such as breast or prostate that have been much studied and have well-defined biology, until recently, relatively few researchers investigated the molecular basis of HNC, making it difficult to design targeted treatments with better efficacy and less debilitating side effects. This volume will provide an overview of the factors contributing to disease pathogenesis, including the recognition of discrete molecular subtypes with distinct etiology, prognosis, and treatment response. This volume will familiarize the reader with the critical signaling pathways and oncogenic drivers for HNC. It will outline the differences between HPV-positive and HPV-negative disease, and how these differences affect treatment choice and outcome. The book will emphasize developments in the past five years, including the growing understanding of the genomic and epigenomic features of the disease based on analysis of next generation sequencing (NGS) data, and timely topics such as the analysis of HNC stem cell populations, non-coding mRNAs, and inflammatory response. It will address exciting new therapeutic approaches such as the use of immunotherapies to treat HNC patients. Overall, the book will provide the reader with current understanding of the biology and treatment of the disease, and describe timely questions that will guide future research aimed at controlling and curing this disease.

Observation of the Associated Production of a Single Top Quark and a W Boson in Pp Collisions at $\sqrt{s}$

The Black Book of Quantum Chromodynamics

The Black Book of Quantum Chromodynamics is an in-depth introduction to the particle physics of current and future experiments at particle accelerators. The book offers the reader an overview of practically all aspects of the strong interaction necessary to understand and appreciate modern particle phenomenology at the energy frontier. It assumes a working knowledge of quantum field theory at the level of introductory textbooks used for advanced undergraduate or in standard postgraduate lectures. The book expands this knowledge with an intuitive understanding of relevant physical concepts, an introduction to modern techniques, and their application to the phenomenology of the strong interaction at the highest energies. Aimed at graduate students and researchers, it also serves as a comprehensive reference for LHC experimenters and theorists. This book offers an exhaustive presentation of the technologies developed and used by practitioners in the field of fixed-order perturbation theory and an overview of results relevant for the ongoing research programme at the LHC. It includes an in-depth description of various analytic resummation techniques, which form the basis for our understanding of the QCD radiation pattern and how strong production processes manifest themselves in data, and a concise discussion of numerical resummation through parton showers, which form the basis of event generators for the simulation of LHC physics, and their matching and merging with fixed-order matrix elements. It also gives a detailed presentation of the physics behind the parton distribution functions, which are a necessary ingredient for every calculation relevant for physics at hadron colliders such as the LHC, and an introduction to non-perturbative aspects of the strong interaction, including inclusive observables such as total and elastic cross sections, and non-trivial effects such as multiple parton interactions and hadronization. The book concludes with a useful overview contextualising data from previous experiments such as the Tevatron and the Run I of the LHC which have shaped our understanding of QCD at hadron colliders.