Mechanisms Of Tolerance And Dependence
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Principles of Pharmacology
Author: David E. Golan
language: en
Publisher: Lippincott Williams & Wilkins
Release Date: 2008
This primary textbook for a first course in pharmacology offers an integrated, systems-based, and mechanism-based approach to understanding drug therapy. Each chapter focuses on a target organ system, begins with a clinical case, and incorporates cell biology, biochemistry, physiology, and pathophysiology to explain how and why different drug classes are effective for diseases in that organ system. Over 400 two-color illustrations show molecular, cellular, biochemical, and pathophysiologic processes underlying diseases and depict targets of drug therapy. Each Second Edition chapter includes a drug summary table presenting mechanism, clinical applications, adverse effects, contraindications, and therapeutic considerations. New chapters explain how drugs produce adverse effects and describe the life cycle of drug development. The fully searchable online text and an image bank are available on thePoint.
Physics, Pharmacology and Physiology for Anaesthetists
Author: Matthew E. Cross
language: en
Publisher: Cambridge University Press
Release Date: 2008-03-27
The FRCA examination relies in part on a sound understanding of the basic sciences (physics, physiology, pharmacology and statistics) behind anaesthetic practice. It is important to be able to describe these principles clearly, particularly in the viva section of the examination. This book provides the reader with all the important graphs, definitions and equations which may be covered in the examination, together with clear and concise explanations of how to present them to the examiner and why they are important. Particular attention is paid to teaching the reader how to draw the graphs. This is an aspect of the examination which can be overlooked but which, if done well, can create a much better impression in the viva situation. Packed full of precise, clear diagrams with well structured explanations, and with all key definitions, derivations and statistics, this is an essential study aid for all FRCA examination candidates.
Psychoactive Drugs
Author: A. J. Goudie
language: en
Publisher: Springer Science & Business Media
Release Date: 1989-09
Research into the processes of tolerance and sensitization has escalated at a substantial rate in recent years, presumably because of the fundamental importance of understanding the long-term, as opposed simply to the initial, acute effects of drugs. The rapid of such research in recent years is documented c1early by growth the editors in the introductory chapter to this text. However, despite the fact that there is a very large amount of literature concemed with the effects of long-term drug treatment, there is, to the best of our knowledge, no published text that has ever attempted to integrate some of the many diverse findings that have been made in this area. Basic research has uncovered a num ber of different mechanisms by which tolerance and sensitization to drugs can develop. Such mechanisms are of very different types, involving psychological behavioral, metabolic, neuronal, and subcellular processes. Because of the complexity of each of these different types of mechanisms, with few exceptions, individual re searchers usually tend, understandably, to concentrate on their own specific areas of expertise, paying relatively little attention to rele vant research occurring in other areas. Consequently, they neglect or simply ignore the important question of the relative importance of the specific mechanism that they are studying, and the related question of the possible interrelationships that may exist between different mechanisms for the production of tolerance and sensitiza tion.