Ananyaa Kumar Silverlake
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PEGylated Protein Drugs: Basic Science and Clinical Applications
Author: Francesco M. Veronese
language: en
Publisher: Springer Science & Business Media
Release Date: 2009-12-30
PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.
Architecture and the Smart City
Increasingly the world around us is becoming ‘smart.’ From smart meters to smart production, from smart surfaces to smart grids, from smart phones to smart citizens. ‘Smart’ has become the catch-all term to indicate the advent of a charged technological shift that has been propelled by the promise of safer, more convenient and more efficient forms of living. Most architects, designers, planners and politicians seem to agree that the smart transition of cities and buildings is in full swing and inevitable. However, beyond comfort, safety and efficiency, how can ‘smart design and technologies’ assist to address current and future challenges of architecture and urbanism? Architecture and the Smart City provides an architectural perspective on the emergence of the smart city and offers a wide collection of resources for developing a better understanding of how smart architecture, smart cities and smart systems in the built environment are discussed, designed and materialized. It brings together a range of international thinkers and practitioners to discuss smart systems through four thematic sections: ‘Histories and Futures’, ‘Agency and Control’, ‘Materialities and Spaces’ and ‘Networks and Nodes’. Combined, these four thematic sections provide different perspectives into some of the most pressing issues with smart systems in the built environment. The book tackles questions related to the future of architecture and urbanism, lessons learned from global case studies and challenges related to interdisciplinary research, and critically examines what the future of buildings and cities will look like.
The Man Who Bent Light
The father of fiber optics, Narinder Singh Kapany was far more than your typical multi-hyphenate. Inventor, art collector, sculptor, farmer, entrepreneur, teacher, and a successful businessman, Dr Kapany was what Fortune magazine in its 1999 issue called, 'one of the seven unsung heroes of the 20th century'. An insightful and inspirational life story, this memoir chronicles his 90 remarkable years. Charming, idiosyncratic, and highly engaging, The Man who Bent Light serves up enough variety and verve to celebrate the lives of a half-dozen individuals. But there is only one Narinder Singh Kapany, and his life, illuminated in his singular memoir, is a life like no other.