Advancing Development
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The Commonwealth Guide to Advancing Development Through Sport
A Guide for governments and stakeholders seeking to strengthen the contribution of sport to development and peace work. Part 1 provides evidence-based analysis of the potential contribution of sport to development objectives. Part 2 provides a practical framework for analysis, planning and monitoring of sport in development and peace work.
Advancing Development of Synthetic Gene Regulators
This book focuses on an “outside the box” notion by utilizing the powerful applications of next-generation sequencing (NGS) technologies in the interface of chemistry and biology. In personalized medicine, developing small molecules targeting a specific genomic sequence is an attractive goal. N-methylpyrrole (P)–N-methylimidazole (I) polyamides (PIPs) are a class of small molecule that can bind to the DNA minor groove. First, a cost-effective NGS (ion torrent platform)-based Bind-n-Seq was developed to identify the binding specificity of PIP conjugates in a randomized DNA library. Their biological influences rely primarily on selective DNA binding affinity, so it is important to analyze their genome-wide binding preferences. However, it is demanding to enrich specifically the small-molecule-bound DNA without chemical cross-linking or covalent binding in chromatinized genomes. Herein is described a method that was developed using high-throughput sequencing to map the differential binding sites and relative enriched regions of non-cross-linked SAHA-PIPs throughout the complex human genome. SAHA-PIPs binding motifs were identified and the genome-level mapping of SAHA-PIPs-enriched regions provided evidence for the differential activation of the gene network. A method using high-throughput sequencing to map the binding sites and relative enriched regions of alkylating PIP throughout the human genome was also developed. The genome-level mapping of alkylating the PIP-enriched region and the binding sites on the human genome identifies significant genomic targets of breast cancer. It is anticipated that this pioneering low-cost, high through-put investigation at the sequence-specific level will be helpful in understanding the binding specificity of various DNA-binding small molecules, which in turn will be beneficial for the development of small-molecule-based drugs targeting a genome-level sequence.
Mastering Bootstrap, AJAX, and jQuery for Elevating Web Experiences with Advanced Development Techniques
Author: Dr. Poornima G. Naik Dr. Girish R. Naik
language: en
Publisher: Shashwat Publication
Release Date: 2024-04-25
Proficiency in Bootstrap, AJAX, and jQuery is paramount in modern web development due to their significant contributions to creating engaging and functional web applications. Bootstrap, with its extensive library of pre-designed components and responsive grid system, expedites UI development while ensuring consistency and adaptability across various devices and screen sizes. AJAX empowers developers to implement dynamic and asynchronous communication between the client and server, enabling real-time updates without requiring full page reloads. This enhances user experience by providing smoother interactions and reducing latency, crucial for today's fast-paced digital environments. Further, jQuery simplifies client-side scripting by abstracting complex JavaScript operations into concise and reusable functions, facilitating efficient DOM manipulation, event handling, and AJAX requests. Mastery of these technologies not only aligns developers with industry standards but also enhances the employability opportunities by demonstrating their ability to create visually appealing, responsive, and interactive web applications that meet the evolving demands of users and businesses alike in the competitive web development landscape. This book offers a comprehensive hands-on experience designed to equip readers with mastery over fundamental concepts in web development.