Activation And Inhibition Of The Interferon Induced Double Stranded Rna Dependent Protein Kinase And Their Effects On Gene Expression
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Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates
Author: W.E.G. Müller
language: en
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.
dsRNA Genetic Elements
Our understanding of the nature, origin, and biological roles of double-stranded RNA found in fungi, plants, and animals has advanced greatly during the last five years. Because these genetic elements are capable of replication, they can be used to manage fungal diseases of crops, vegetables, turfgrass, fruit, and forest trees using genetic means r